To our community: Due to circumstances surrounding COVID-19, Clinical Research IO had to make the difficult decision to discontinue funding for Caretalk. We've decided to leave the website up as a resource for the community. Thank you so much to everyone who made this possible, and please enjoy!

What is Clinical Research?

Reviewed by Sowmya Chary, MD, MMSc(c) - Sri Ramachandra Institute of Higher Education and Research, Harvard Medical School

Clinical trials are one of the cornerstones of medical innovation in Alzheimer's Disease. Almost all of the treatments we rely on today were tested in trials, and there are tens of thousands of clinical trials--testing the treatments of tomorrow--going on right now. Keep scrolling to learn more about this process or find trials near you.

The Stages of Clinical Research

Phase 1

Phase 1 (or "first-in-human") trials study the safety and toxicity of a new intervention. The participants are often healthy volunteers, rather than patients.

Phase 2

Phase 2 trials are the first tests of an experimental treatment's efficacy against a particular disease or condition. The participants are usually patients who do not benefit from the available therapies.

Phase 3

Phase 3 (or "pivotal") trials are the decisive tests that regulators use to decide if a treatment should be approved for general use. These studies usually randomize patients to receive either the experimental treatment or a control treatment, like a placebo or a medication already approved to treat the condition.

Phase 4

Phase 4 (or "post-marketing") trials are conducted after a treatment has received regulatory approval. These are often very large studies that will focus on long-term safety and efficacy outcomes.

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