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Beta-Amyloid Plaques

Reviewed by Benedict Albensi, PhD, BCMAS, CRQM

Amyloid precursor protein (APP) is a small protein in the brain that typically gets cut into fragments. However, in people with Alzheimer's Disease, the cutting of APP results in the appearance of beta-amyloid, a toxic protein fragment which starts to stick together to form microscopic amyloid plaques. When these plaques start accumulating in the brain, they prevent neurons (brain cells) from communicating with each other, disrupting a person's cognition. A popular focus of Alzheimer's research has been towards altering APP or removing beta-amyloid plaques.

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